Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research

Here we aim to investigate the relationship between olfactory and motor system in the brain. We are particularly interested in exploring how pleasant and unpleasant odors will impact corticospinal accessibility and effective connectivity in both normal and pathological condition. Exploring the mechanistic basis of olfactory motor interactions requires careful consideration of two methodological aspects.

First, it is imperative to deliver different olfactory condition within the same experimental phase. Second, precise control and synchronization of olfactory and TMS stimulations with respiratory phases is required. We present a new method designed for the rigorous investigations of the modulations of corticospinal excitability and effective connectivity that might occur during the perception of pleasant and unpleasant odors.

All these stimulations are delivered in synchrony with human nasal breathing. This method paved the way for clinical investigation exploring aberrant interactions between olfactory and motor system. We are currently applying these methods to patients with psychiatric disorders that are associated with alterations in the autonomic perception of odors and maladaptive approach or avoidance behaviors.