This work was supported, in part by the NIBIB (EB007954) and a charitable donation from Geraldine Warner.

The protocol described below has components of a vision training program that is a part of the baseline testing performed on all UC athletes. Some of the components have been studied in research trials and in these instances the protocols were approved by the UC Institutional Review Board and the subjects signed informed consent statements.
1. Light Board Vision Training
It takes about 8 min to complete this training.
<ol>
	<li>*A Program8-11
	<ol>
		<li>Direct the subject to stand about 18 inches away from the light board and have the subject try to reach the lights in the outer ring. Move the subject closer or farther away if needed in order to reach all of the lights. Additionally, move the light board up and down using a power switch on the side so the subject is at eye-level with the screen in the board. 
		Have the subject stand in a ready position to be able to hit the lights. Have the subject hold his/her hands up to chest level to position the hands in the center of the rings.</li>
		<li>Instruct the subject to hit the lights using both hands as fast as possible and deactivate as many as possible in one minute. Each light will remain illuminated until hit. 
		Note: When a subject successfully hits a light there is a beep that they can hear in addition to the light turning off.</li>
		<li>Have the clinician select the *A program and have the subject hit (deactivate) as many lights as possible in one minute. With experience a subject will become comfortable with the menu for the system and be able to start the *A without assistance from the clinician, if desired.</li>
		<li>Record the number of hits per minute for each session to track progress along with the average reaction time in seconds for the hits during the one minute test.</li>
	</ol>
	</li>
	<li>Reaction Test Program11 
	Note: The Reaction Test Program consists of six different tests, three for the right hand and three for the left hand.
	<ol>
		<li>Instruct the subject to select the Reaction Test and hit start. The lights for Test 1R (right hand) will light sequentially three times to show the subject which lights they will be hitting. Once the lights are done flashing in sequence, there will be a light to the right that will be lit for the first test. Four horizontal lights to the left of the center ring are utilized for Test 1R and the four to the right of the center are utilized for Test 1L.</li>
		<li>Instruct the subject to hold down the lit light to the right (with right hand) and stand in front of and in the middle of the row of lights that lit up during the demonstration. Have the subject hold the left hand behind his/her back.</li>
		<li>Have the subject scan the four horizontal lights that light up during the demonstration sequence. One of the four lights will come on randomly within five seconds. The distance between each light in the horizontal row is 14 inches. Have the subject move the right hand from the initial light to the reaction light as quickly as possible and deactivate it (Figure 1A-C).</li>
		<li>Once the subject completes a pre-determined number of hits, typically 5 times, instruct him/her to press the GREEN light at the bottom of the inner ring of lights. This will show the subject which lights for the next test will be involved. When ready, the subject holds down the lit light on the left, holds the right hand behind the back, and follows the above procedures. Point out to the subject to disregard the bottom green light during these tests as it is used to change from one test to another but is not one of the lights to be hit. 
		Note: Tests 1R and 1L involve a linear random target switch. Tests 2R and 2L are again random, unknown targets, which will appear along an arc in one of eight different planes. It is the middle ring of lights that is used for Test 2R and 2L. Tests 3R and 3L are a simple one light choice using the lights to the right and left of the t-scope.</li>
		<li>Record the average reaction time for each Test plus an overall Reaction Time.</li>
	</ol>
	</li>
	<li>Concussion 1-3 Programs (novel programs developed by author JFC). 
	Note: The three programs are designed to be performed in sequence. The learning effect is seen in normal individuals. However, in concussion patients the learning effect is not seen and is considered as diagnostic for concussion. These programs are used for testing, not training. For the concussion testing the Dynavision *A and Dynavision Reaction Test can be used for baseline assessments. The three concussion tests are also used for concussion assessment but are generally not done by subjects in advance. The three concussion tests are designed to be multi-tasking and executive function tests that the subjects have not seen before7.
	<ol>
		<li>Conduct the Concussion 1 program, a one minute test that uses only the middle three concentric rings. The test is similar to the *A test, except the subject has single digit numbers (random numbers 1 through 9) flashing on the programmable screen for one second at eight second intervals. Ask the subject to read the numbers flashed on the screen out loud to the tester while still hitting the buttons that are lighting. The resultant score is the number of hits per minute and a report of missed numbers (if any).</li>
		<li>Conduct the Concussion 2 program, which is similar to Concussion 1 in that single digit numbers flash on screen. Instruct the subjects to call out the first number while still hitting buttons, remember it, and then when the second number flashes, add the first and second numbers together and call out the sum of the numbers. The subject continues to hit buttons while calling and adding numbers in pairs.</li>
		<li>Conduct the Concussion 3 program, which is similar to Concussion 2 with one additional task; 20% of the buttons are green. The subject is instructed to hit buttons and add numbers in pairs similar to the instructions in 1.3.2. In addition to those tasks, instruct the subject to hit the green buttons and also call out green. Therefore, there are two speaking tasks, calling green while calling and adding numbers in pairs. This is all done while hitting the both colors of buttons.</li>
	</ol>
	</li>
</ol>
2. Brock&#8217;s String6,10,12
<ol>
	<li>Hold one end of the Brock string on the tip of the subject&#8217;s nose while the other end is tied to a fixed point. The fixed point can be horizontal, elevated or declined with respect to the height of the nose point. Neutral is straight ahead (horizontal). The up or down angle should not be more than 45&#176; in either direction. Initially the string is held in the horizontal position and then typically the elevation is progressed from 10&#176; to 25&#176; to 45&#176; over a time frame where the tasks are challenging but still comfortable. With some people who have prominent noses or eye brows there may be anatomic limitations that need to be observed.</li>
	<li>Space the five colored beads on a length of string at least 12 inches apart starting about 10 inches from the nose. Instruct the subject to alternate &#64257;xation and focus from one bead to the next while noting the visual input of each eye and sensation of convergence (formation of an image at a single point). A measurement is not recorded as this is used as an exercise instead of a test.
	<ol>
		<li>Vary the spacing according to subject&#8217;s needs. Needs may be based on sport or task. For example, combat sports such as boxing may need more beads less than 3 feet away, whereas field sports such as football and soccer might need beads around 10 feet (Figure 2A-C).</li>
	</ol>
	</li>
	<li>Alternatively, use a task where the string is six feet and tied off at one end. Many people have a reach from their nose to the tip of their fingers of 4 feet. The farthest bead is placed at the extreme reach of the index finger. The subject touches the bead with his index finger and returns it to the side of the leg, alternating the right and left hands.</li>
	<li>Alternatively, use a wand with tape the color of the ball on the Brock string. Space the tape three inches apart. When performing the exercise, instruct the subject to match the color of the tape on the wand to the color of the ball, calling out each color as he matches ball to tape.</li>
</ol>
3. EYEPORT Training13
<ol>
	<li>For training 1, place alternating red and blue linear lights in the horizontal position and instruct the subject to sit 24 to 30 inches from the system. Have the subject hit the enter button to hear ten beeps and then follow the lights with his/her eyes. When the exercise is over the subject will hear a beep and should then close his/her eyes and rest until the next exercise.</li>
	<li>For training 2, place the linear lights in the vertical position and repeat steps for Exercise 1.</li>
	<li>For training 3, rotate the linear lights to the left from the vertical position and repeat steps for Exercise 1. Rotation is done in stages through 360&#176;. Common stages are 20 degrees at a time providing it is comfortable for the subject.</li>
	<li>For training 4, rotate the linear lights to the right from the vertical position and repeat steps for Exercise 1.</li>
	<li>For training 5, reposition the linear lights so the system touches the end of the subject&#8217;s nose. Instruct the subject to follow the lights from near to far and far to near. 
	Note: Instruct the subject to rest after each exercise before going to the next one. A measurement is not recorded as this is used as an exercise instead of a test.</li>
</ol>
4. Accommodative Flippers
<ol>
	<li>Allow the subject to wear his/her habitual prescriptions. Perform all training binocularly. The power of the flipper lenses used is varied to optimize the training effect. The two powers used should be challenging but not onerous to focus on an object as the flippers are alternated.</li>
	<li>Instruct the subject to hold a 10 x 10 saccades chart at 14 inches from the spectacle plane.</li>
	<li>Instruct the subject to read from left to right while moving the flippers up and down repeatedly. The flippers are moved only after the subject can focus on and read the saccade card.</li>
	<li>Test for one minute or until the 100th character is reached.</li>
	<li>Count and record the number of characters read in the one minute or note the time it takes to read 100.</li>
</ol>
5. Tachistoscope
Note: This training uses a PowerPoint presentation designed by author J Clark.
<ol>
	<li>Have the subject watch the timed presentation and make note of one or two specific bits of information based on questions posed after the flash. Typically several subjects can work on the projected tachistoscope training simultaneously.</li>
	<li>As the flashed pictures have numbers and or letters randomly distributed throughout the pictures, have the subject note the numbers/letters. Also, ask additional questions such as player numbers from the photos, teams being played, etc.</li>
	<li>Make the tachistoscope training progressively more complicated, by making the flash time shorter and/or the information to be obtained more complicated. (Figure 3A and B). The percentage of questions answered correctly can be recorded.</li>
</ol>
6. Pinhole Glasses or Strobe Glasses with Pitch and Catch
<ol>
	<li>Give groups of subjects, typically two to six subjects, with 1 or 2 balls, pinhole glasses (Figure 4A) or strobe glasses (Figure 4B) and advise to throw the ball(s) around for approximately 2-5 min per session. (Figure 4C and 4D) Two to three sessions per week can be performed.</li>
	<li>If strobe glasses and pinhole glasses are available, have subjects rotate strobes and pinhole glasses every minute or two. Strobe glass flash speeds start at the faster speeds and are slowed to make the tasks more challenging. Current strobe glasses have 8 speeds so typical starting speeds are 1 or 2, and are slowed to speeds 4 to 6.</li>
	<li>Progress through the pitch and catch tasks throughout the sessions by varying the speed of the flash with the strobes or narrowing the visual field of the pinhole glasses.</li>
	<li>Also, make the pitch and catch routines more complicated by having subjects turn away from their partner and having to turn and catch. A measurement is not recorded as this is used as an exercise instead of a test.</li>
</ol>
7. Saccadic Eye Movement Training6,10,14
<ol>
	<li>Position the subject eight feet away from the saccadic eye charts and centered between two saccadic charts, which are positioned about eight feet from the center line. Prior to beginning the exercise, ensure that the subject has full range of eye motion in order to see all letters on the saccadic chart. Adjust the distance from the charts accordingly to gain full vision of the chart. 
	Note: It is important to change distances to add a dynamic component to the accommodative systems and therefore subjects are asked to stand 8 feet away as opposed to the 18 inches used for light board training. There are vision training programs out there that use only a computer and computer screen and do not exercise the accommodative systems. So vary the lengths at which the tasks are performed. Each saccadic chart is constructed on an 8.5 x 11 inch sheet of paper. Each chart has 10 letters in a 36 point font per vertical line with 10 vertical lines on the chart (Figure 5).</li>
	<li>Instruct the subject to read the charts for one minute each while keeping his/her head still and only moving his/her eyes. Ask the subject to read the first letter on the first line on the first chart and then alternate to the second chart to read the first letter of the first line. This completes one cycle.</li>
	<li>Instruct the subject to read the second letter of the left chart followed by the second letter of the right chart. This completes another cycle. Alternate between charts and letters progressing across the line horizontally. As the subjects complete the first line on both charts, instruct them to move to the next line, etc., for one minute. Record the number of cycles completed in the one minute.</li>
	<li>Place the charts at eye level and distance them six feet apart. A progression of this training exercise includes using unstable surfaces and varying placement of the charts to enhance eye speed and visual focus.</li>
</ol>
8. Near Far Training6,10,14
<ol>
	<li>Utilize two charts for this exercise - a large chart and a smaller one. Use the saccadic eye chart for the large chart. Construct the small chart on a 3.5 x 2.5 inch sheet of paper where there are 10 letters in a 12 point font per vertical line with 10 vertical lines on the chart.</li>
	<li>Fix the far chart at eye level with the subject positioned 10 feet from the chart. Have the subject hold the near chart with one hand approximately 4-6 inches from the nose. This allows the subject to see over the near chart to see the far chart (Figure 6A).</li>
	<li>Instruct the subject to keep his head still and only move the eyes. Ask the subject to read the first letter on the first line of the far chart and then alternate to the near chart to read the first letter of the first line. This completes one cycle (Figure 6B and 6C).</li>
	<li>Have the subject scan the eyes to read the second letter of the far chart followed by the second letter of the near chart. This completed another cycle.</li>
	<li>Instruct the subject to alternate between charts and letters progressing across lines horizontally. As the first line on both charts is completed, have the subject move to the next line until the time expires for the one minute session. Record the number of cycles completed in the one minute.</li>
	<li>Instruct the subject to be sure that both eyes come into focus on the near target as well as the far target when alternating from chart to chart.</li>
</ol>
9. Stereopsis
<ol>
	<li>Place polarizing glasses on the subject and ask if &#8220;the Stereo Fly&#8217;s wings appear to be standing up at them and in three dimensions?&#8221;</li>
	<li>Instruct subjects to observe the Stereo Fly at a distance of 14 inches from their nose. If the response is positive, instruct subjects to &#8220;reach out and point with a pen to the Stereo Fly&#8217;s right wing tip and to hold that position&#8221; (Figure 7A).</li>
	<li>Record the distance between the photo and the center of the pinch with a millimeter ruler (Figure 7B). 
	Note: The higher the number, in mm, is indicative of better stereopsis when measured on the Stereo Fly15. Based on our experience we have found that 85 mm appears to be the upper limit of the distance from the photo to the center of the pinch3.</li>
</ol>

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The authors have nothing to disclose.
The Dynavision D2 may be a tool that clinical practitioners can use to provide added information concerning neurologic health of the athlete with a concussion10,22,23,27. The device does not make the diagnosis but assists the clinician in making a clinical decision by providing objective measures of the performance parameters for that patient or athlete.

Vision training, when initiated as a team wide exercise, decreases the incidence of concussions in those players when compared to players who do not receive the vision training7. Vision training produces functional and performance changes that can be quantitatively monitored to assess the success of the training and can be initiated as part of a sports medical intervention for concussion prevention. Functional changes are changes in the measurement, for example faster reaction times documented during vision tr...

Vision training, including the use of light board vision systems, has gained popularity as a means to improve sports performance1,2. Light board systems are often used for rehabilitation following brain injury2,3 and for sports performance enhancement as part of a vision training regimen1,4,5. Vision training has also been used as a means of injury prevention6.
The University of Cincinnati (UC) Division of Sports Medicine has used a light board vision tool for concussion management, diagnosis, return to play decision making, injury prevention and rehabilitation of athletes and performance enhancement3,5,7. Each athlete has baseline measurements collected at the beginning of the season and these values are used as a part of the concussion management program and specifically for an athlete&#8217;s post-concussion evaluation and treatment. One of the strengths of the tool is the objective data collected: number of hits per unit time, location within the visual field of each hit, average reaction time per hit, multi-tasking drills and temporal output for observing progress.
The UC sports medicine team has used the *A and Reaction Test as part of concussion baseline assessments. Three additional, purpose built, programs are also used for concussion diagnosis. These are called Concussion 1, Concussion 2 and Concussion 3. The 3 concussion tests do not need to be included among the preseason baseline tests, because their differing levels of complexity allow each test result to serve as a reference for the others in the set.
When the programs are complemented with additional vision training methods the athlete gets a thorough training and the clinician obtains a wealth of baseline data in the event of a concussion. Several additional vision training methods complete the comprehensive program: Brock&#8217;s string, EYEPORT training, accommodative flippers, tachistoscope, pinhole glasses or strobe glasses with pitch and catch, saccadic eye movement training, and near far training. This paper presents vision training methods with and without a light board system, normative data for baseline results for Division 1 college football players, and expectations and protocols concerning the use of the vision training protocol as part of a concussion management program.

<table border="0" cellpadding="0" cellspacing="0">
	<tbody>
		<tr>
			<td>Name of Material/ Equipment</td>
			<td>Company</td>
			<td>Catalog Number</td>
			<td>Comments/Description</td>
		</tr>
		<tr>
			<td>Dynavision D2</td>
			<td>Dynavision International</td>
			<td></td>
			<td><a href="http://dynavisioninternational.com/shop.html">External Link</a></td>
		</tr>
		<tr>
			<td>EYEPORT Vision Training System</td>
			<td>Exercise Your Eyes, Dove Canyon, CA</td>
			<td></td>
			<td><a href="http://www.promolife.com/cart/eyeport-vision-training-system">External Link</a></td>
		</tr>
		<tr>
			<td>accommodative flippers</td>
			<td>Various manufacturers</td>
			<td></td>
			<td><a href="http://www.amconlabs.com/product.asp?pid=4511&amp;categoryname=&amp;prodCatFrom=206">External Link</a></td>
		</tr>
		<tr>
			<td>pinhole glasses</td>
			<td>Various manufacturers</td>
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		</tr>
		<tr>
			<td>strobe glasses - Nike Sparq</td>
			<td>Nike&#160;</td>
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		</tr>
	</tbody>
</table>

vision training methods for sports concussion mitigation and management

There is emerging evidence supporting the use vision training, including light board training tools, as a concussion baseline and neuro-diagnostic tool and potentially as a supportive component to concussion prevention strategies. This paper is focused on providing detailed methods for select vision training tools and reporting normative data for comparison when vision training is a part of a sports management program. The overall program includes standard vision training methods including tachistoscope, Brock&#8217;s string, and strobe glasses, as well as specialized light board training algorithms. Stereopsis is measured as a means to monitor vision training affects. In addition, quantitative results for vision training methods as well as baseline and post-testing *A and Reaction Test measures with progressive scores are reported. Collegiate athletes consistently improve after six weeks of training in their stereopsis, *A and Reaction Test scores. When vision training is initiated as a team wide exercise, the incidence of concussion decreases in players who participate in training compared to players who do not receive the vision training. Vision training produces functional and performance changes that, when monitored, can be used to assess the success of the vision training and can be initiated as part of a sports medical intervention for concussion prevention.

Baseball, football and volunteer subjects have participated in the vision training program. All subjects have been college age men or women, between the ages of 18- and 26 years-old.
Football
The average *A score for 101 UC Football players the first time they performed it was 74.2 &#177; 10.3 hits per min (hpm) and the average Reaction Test time for their first time performing it was 0.34 &#177; 0.03 sec (n = 79, note not all 105 players had a chance to complete th...

Watch this Scientific Journal Video about Vision Training Methods for Sports Concussion Mitigation and Management at JoVE.com

Vision Training Methods for Sports Concussion Mitigation and Management

This paper describes a protocol to conduct, quantitatively monitor, and assess the success of vision training initiated as part of a sports medical management program including intervention for concussion prevention and performance enhancement.

There is emerging evidence supporting the use vision training, including light board training tools, as a concussion baseline and neuro-diagnostic tool ...

vision-training-methods-for-sports-concussion-mitigation

Research

JoVE Journal

Behavior

17.3K 조회수.  University of Cincinnati. This paper describes a protocol to conduct, quantitatively monitor, and assess the success of vision training initiated as part of a sports medical management program including intervention for concussion prevention and performance enhancement.

비디오: Vision Training Methods for Sports Concussion Mitigation and Management

An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System

One of the most commonly reported injuries in children who participate in sports is concussion or mild traumatic brain injury (mTBI)1. Children and youth involved in organized sports such as competitive hockey are nearly six times more likely to suffer a severe concussion compared to children involved in other leisure physical activities2. While the most common cognitive sequelae of mTBI appear similar for children and adults, the recovery profile and breadth of consequences in children remains largely unknown2, as does the influence of pre-injury characteristics (e.g. gender) and injury details (e.g. magnitude and direction of impact) on long-term outcomes. Competitive sports, such as hockey, allow the rare opportunity to utilize a pre-post design to obtain pre-injury data before concussion occurs on youth characteristics and functioning and to relate this to outcome following injury. Our primary goals are to refine pediatric concussion diagnosis and management based on research evidence that is specific to children and youth. To do this we use new, multi-modal and integrative approaches that will:
 1.Evaluate the immediate effects of head trauma in youth 
2.Monitor the resolution of post-concussion symptoms (PCS) and cognitive performance during recovery 
3.Utilize new methods to verify brain injury and recovery
To achieve our goals, we have implemented the Head Impact Telemetry (HIT) System. (Simbex; Lebanon, NH, USA). This system equips commercially available Easton S9 hockey helmets (Easton-Bell Sports; Van Nuys, CA, USA) with single-axis accelerometers designed to measure real-time head accelerations during contact sport participation 3 - 5. By using telemetric technology, the magnitude of acceleration and location of all head impacts during sport participation can be objectively detected and recorded. We also use functional magnetic resonance imaging (fMRI) to localize and assess changes in neural activity specifically in the medial temporal and frontal lobes during the performance of cognitive tasks, since those are the cerebral regions most sensitive to concussive head injury 6. Finally, we are acquiring structural imaging data sensitive to damage in brain white matter.

This article provides an overview of a multi-modal approach to mild traumatic brain injury diagnosis and recovery in youth. This approach combines neuropsychological testing with functional magnetic resonance imaging and the Head Impact Telemetry System to monitor the relationship between head impacts and brain activity during cognitive testing.

One of the most commonly reported injuries in children who participate in sports is concussion or mild traumatic brain injury (mTBI)1. Children and youth ...

Medicine

In Vivo Protocol of Controlled Subconcussive Head Impacts for the Validation of Field Study Data

Subconcussive hits pose a threat to neuronal health as they have shown to induce neuronal structural damage and functional impairment without causing outward symptomology and appear to be a key contributor to an irreversible neurodegenerative disease, chronic traumatic encephalopathy (CTE). In addition, athletes can incur more than 1,000 of these hits per season. The subconcussive soccer heading model (SSHM) is a relevant, reproducible, and leading method of isolating and examining the effects of these subconcussive head impacts. By controlling variables such as ball traveling speed, the frequency of impacts, interval, ball placement to the head, as well as by measuring head impact magnitude, the SSHM provides the scientific community with a superior avenue of investigating the acute subconcussive effects on neuronal health. In this paper, we demonstrate the utility of SSHM in studying a time-course expression of neurofilament-light polypeptide (NF-L) in plasma in a repeated measures fashion. NF-L is an axonal injury marker that has previously been shown to be elevated in boxers and football players following subconcussive head trauma. Thirty-four adult aged soccer players were recruited and randomly assigned to either a soccer heading (n = 18) or kicking (n = 16) group. The heading group executed 10 headers with soccer balls projected at a velocity of 25 mph over 10 min. The kicking group followed the same protocol with 10 kicks. Plasma samples were obtained before and at 0 h, 2 h, and 24 h after heading/kicking and assessed for NF-L expressions. The heading group showed a gradual increase in plasma NF-L expression and peaked at 24 h after the heading protocol, whereas the kicking group remained consistent across the time points. These results confirmed the NF-L data from clinical field studies, encouraging the use of SSHM to validate clinical subconcussion data.

The subconcussive soccer heading model is a safe and concise methodological approach to isolate and measure the effects of subconcussive head impacts.

Subconcussive hits pose a threat to neuronal health as they have shown to induce neuronal structural damage and functional impairment without causing ...

Modified Drop Tower Impact Tests for American Football Helmets

A modified National Operating Committee on Standards for Athletic Equipment (NOCSAE) test method for American football helmet drop impact test standards is presented that would provide better assessment of a helmet's on-field impact performance by including a faceguard on the helmet. In this study, a merger of faceguard and helmet test standards is proposed. The need for a more robust systematic approach to football helmet testing procedures is emphasized by comparing representative results of the Head Injury Criterion (HIC), Severity Index (SI), and peak acceleration values for different helmets at different helmet locations under modified NOCSAE standard drop tower tests. Essentially, these comparative drop test results revealed that the faceguard adds a stiffening kinematic constraint to the shell that lessens total energy absorption. The current NOCSAE standard test methods can be improved to represent on-field helmet hits by attaching the faceguards to helmets and by including two new helmet impact locations (Front Top and Front Top Boss). The reported football helmet test method gives a more accurate representation of a helmet's performance and its ability to mitigate on-field impacts while promoting safer football helmets.

This article provides a novel technique to assess the performance characteristics of American football helmets by inclusion of faceguards during NOCSAE Standard drop tests. Additionally, two more impact locations are proposed to be added to the NOCSAE certification.

A modified National Operating Committee on Standards for Athletic Equipment (NOCSAE) test method for American football helmet drop impact test standards ...

Bioengineering

Revised and Neuroimaging-Compatible Versions of the Dual Task Screen

Dual task paradigms simultaneously assess motor and cognitive abilities, and they can detect subtle, residual impairments in athletes with recent mild traumatic brain injury (mTBI). However, past dual task paradigms have focused solely on lower extremity skills and have relied on cumbersome, expensive laboratory equipment - thus limiting their practicality for everyday mTBI evaluation. Subsequently, we developed the Dual Task Screen (DTS), which takes &#60;10 minutes to administer and score, uses low-cost portable equipment, and includes lower extremity (LE) and upper extremity (UE) subtasks. The purpose of this manuscript was twofold. First, we describe the administration protocol for the revised DTS, which we revised to address the limitations of the original DTS. Specifically, the revisions included additions of smart devices to acquire more detailed gait data and inclusion of single cognitive conditions to test for disrupted cognitive performance under dual task conditions. Importantly, the revised DTS is a measure intended for future clinical use, and we present representative results from three male athletes to illustrate the type of clinical data that can be acquired from the measure. Importantly, we have yet to evaluate the sensitivity and specificity of the revised DTS in athletes with mTBI, which is the next research initiative. The second purpose of this manuscript is to describe a neuroimaging-compatible version of the DTS. We developed this version so we could evaluate the neural underpinnings of single and dual task performance, for a better empirical understanding of the behavioral deficits associated with mTBI. Thus, this manuscript also describes the steps we took to enable simultaneous functional near-infrared spectroscopy (fNIRS) measurement during the DTS, along with how we acquired and completed first-level processing of the fNIRS data.

We developed the original Dual Task Screen (DTS) as a portable, low-cost measure that can evaluate athletes with sports-induced mild traumatic brain injury. We revised the original DTS for future clinical use and developed a neuroimaging-compatible version of the DTS to measure neural underpinnings of single and dual task performance.

Dual task paradigms simultaneously assess motor and cognitive abilities, and they can detect subtle, residual impairments in athletes with recent mild ...

A Multi-Modal Approach to Assessing Recovery in Youth Athletes Following Concussion

Concussion is one of the most commonly reported injuries amongst children and youth involved in sport participation. Following a concussion, youth can experience a range of short and long term neurobehavioral symptoms (somatic, cognitive and emotional/behavioral) that can have a significant impact on one&#8217;s participation in daily activities and pursuits of interest (e.g., school, sports, work, family/social life, etc.). Despite this, there remains a paucity in clinically driven research aimed specifically at exploring concussion within the youth sport population, and more specifically, multi-modal approaches to measuring recovery. This article provides an overview of a novel and multi-modal approach to measuring recovery amongst youth athletes following concussion. The presented approach involves the use of both pre-injury/baseline testing and post-injury/follow-up testing to assess performance across a wide variety of domains (post-concussion symptoms, cognition, balance, strength, agility/motor skills and resting state heart rate variability). The goal of this research is to gain a more objective and accurate understanding of recovery following concussion in youth athletes (ages 10-18 years). Findings from this research can help to inform the development and use of improved approaches to concussion management and rehabilitation specific to the youth sport community.

This article provides an overview of a multi-modal approach to assessing recovery following concussion in youth athletes. The described protocol uses pre- and post-concussion assessment of performance across a wide variety of domains and can inform the development of improved concussion rehabilitation protocols specific to the youth sport community.

Concussion is one of the most commonly reported injuries amongst children and youth involved in sport participation. Following a concussion, youth can ...

A Neuroscientific Approach to the Examination of Concussions in Student-Athletes

Concussions are occurring at alarming rates in the United States and have become a serious public health concern. The CDC estimates that 1.6 to 3.8 million concussions occur in sports and recreational activities annually. Concussion as defined by the 2013 Concussion Consensus Statement &#8220;may be caused either by a direct blow to the head, face, neck or elsewhere on the body with an &#8216;impulsive&#8217; force transmitted to the head.&#8221; Concussions leave the individual with both short- and long-term effects. The short-term effects of sport related concussions may include changes in playing ability, confusion, memory disturbance, the loss of consciousness, slowing of reaction time, loss of coordination, headaches, dizziness, vomiting, changes in sleep patterns and mood changes. These symptoms typically resolve in a matter of days. However, while some individuals recover from a single concussion rather quickly, many experience lingering effects that can last for weeks or months. The factors related to concussion susceptibility and the subsequent recovery times are not well known or understood at this time. Several factors have been suggested and they include the individual&#8217;s concussion history, the severity of the initial injury, history of migraines, history of learning disabilities, history of psychiatric comorbidities, and possibly, genetic factors. Many studies have individually investigated certain factors both the short-term and long-term effects of concussions, recovery time course, susceptibility and recovery. What has not been clearly established is an effective multifaceted approach to concussion evaluation that would yield valuable information related to the etiology, functional changes, and recovery. The purpose of this manuscript is to show one such multifaceted approached which examines concussions using computerized neurocognitive testing, event related potentials, somatosensory perceptual responses, balance assessment, gait assessment and genetic testing.

There is great variability in an individual&#8217;s risk for concussion and their corresponding recovery. A multifaceted approach to concussion evaluation is warranted; including baseline testing of athletes before participation in sport and timely evaluation post injury. The goal of this protocol is to provide an appropriate multifaceted approach to examine concussions.

Concussions are occurring at alarming rates in the United States and have become a serious public health concern. The CDC estimates that 1.6 to 3.8 ...

Development and Implementation of a Multi-Disciplinary Technology Enhanced Care Pathway for Youth and Adults with Concussion

The evidence-informed standardization of care along disease lines is recommended to improve outcomes and reduce healthcare costs. The aim of this project is to 1) describe the development and implementation of the Concussion Carepath, 2) demonstrate the process of integrating technology in the form of a mobile application to enable the carepath and guide clinical decision-making, and 3) present data on the utility of the C3 app in facilitating decision-making throughout the injury recovery process. A multi-disciplinary team of experts in concussion care was formed to develop an evidence-informed algorithm, outlining best practices for the clinical management of concussion along three phases of recovery &#8211; acute, subacute, and post-concussive. A custom mobile application, the Cleveland Clinic Concussion (C3) app was developed and validated to provide a platform for the systematic collection of objective, biomechanical outcomes and to provide guidance in clinical decision-making in the field and clinical environments. The Cleveland Clinic Concussion app included an electronic incident report, assessment modules to measure important aspects of cognitive and motor function, and a return to play module to systematically document the six phases of post-injury rehabilitation. The assessment modules served as qualifiers within the carepath algorithm, driving referral for specialty services as indicated. Overall, the carepath coupled with the C3 app functioned in unison to facilitate communication among the interdisciplinary team, prevent stagnant care, and drive patients to the right provider at the right time for efficient and effective clinical management.

A multidisciplinary carepath to standardize disparate concussion care was developed and implemented at the Cleveland Clinic. The Cleveland Clinic Concussion (C3) mobile application was used to enable the carepath through biomechanical outcomes characterizing cognitive and motor function. Patient outcomes improved while cost of care was reduced following implementation.

The evidence-informed standardization of care along disease lines is recommended to improve outcomes and reduce healthcare costs. The aim of this project ...

Objectively Assessing Sports Concussion Utilizing Visual Evoked Potentials

A portable system capable of measuring steady-state visual-evoked potentials (SSVEP) was developed to provide an objective, quantifiable method of electroencephalogram (EEG) testing following a traumatic event. In this study, the portable system was used on 65 healthy rugby players throughout a season to determine whether SSVEP are a reliable electrophysiological biomarker for concussion. Preceding the competition season, all players underwent a baseline SSVEP assessment. During the season, players were re-tested within 72 h of a match for either test-retest reliability or post-injury assessment. In the case of a medically diagnosed concussion, players were reassessed again once deemed recovered by a physician. The SSVEP system consisted of a smartphone housed in a VR-frame delivering a 15 Hz flicker stimulus, while a wireless EEG headset recorded occipital activity. Players were instructed to stare at the screen's fixation point while remaining seated and quiet. Electrodes were arranged according to the 10-20 EEG-positioning nomenclature, with O1-O2 being the recording channels while P1-P2 the references and bias, respectively. All EEG data was processed using a Butterworth bandpass filter, Fourier transformation, and normalization to convert data for frequency analysis. Players SSVEP responses were quantified into a signal-to-noise ratio (SNR), with 15 Hz being the desired signal, and summarized into respective study groups for comparison. Concussed players were seen to have a significantly lower SNR compared to their baseline; however, post-recovery, their SNR was not significantly different from the baseline. Test-retest indicated high device reliability for the portable system. An improved portable SSVEP system was also validated against an established EEG amplifier to ensure the investigative design is capable of obtaining research quality EEG measurements. This is the first study to identify differences in SSVEP responses in amateur athletes following a concussion and indicates the potential for SSVEP as an aid in concussion assessment and management.

A portable system capable of measuring steady-state visual-evoked potentials was developed and trialed on 65 amateur rugby players over 18 weeks to investigate SSVEP as a potential electrophysiological biomarker for concussion. Players' baselines were measured pre-season, with retesting for reliability, concussion, and recovery assessment being conducted within controlled time-periods, respectively.

A portable system capable of measuring steady-state visual-evoked potentials (SSVEP) was developed to provide an objective, quantifiable method of ...

Neuroscience

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Mild traumatic brain injuries (mTBIs) are a prevalent health issue in North America. There is increasing pressure to utilize ecologically valid models of closed-head mTBI in the preclinical setting to increase translatability to the clinical population. The awake closed-headed injury (ACHI) model uses a modified controlled cortical impactor to deliver closed-headed injury, inducing clinically relevant behavioral deficits without the need for a craniotomy or the use of an anesthetic.
This technique does not normally induce fatalities, skull fractures, or brain bleeds, and is more consistent with being a mild injury. Indeed, the mild nature of the ACHI procedure makes it ideal for studies investigating repetitive mTBI (r-mTBI). Growing evidence indicates that r-mTBI can result in a cumulative injury that produces behavioral symptoms, neuropathological changes, and neurodegeneration. r-mTBI is common in youths playing sports, and these injuries occur during a period of robust synaptic reorganization and myelination, making the younger population particularly vulnerable to the long-term influences of r-mTBI.
Further, r-mTBI occurs in cases of intimate partner violence, a condition for which there are few objective screening measures. In these experiments, synaptic function was assessed in the hippocampus in juvenile rats that had experienced r-mTBI using the ACHI model. Following the injuries, a tissue slicer was utilized to make hippocampal slices to evaluate bidirectional synaptic plasticity in the hippocampus at either 1 or 7 days following the r-mTBI. Overall, the ACHI model provides researchers with an ecologically valid model to study changes in synaptic plasticity following mTBI and r-mTBI.

Here, it is demonstrated how an awake closed-head injury model can be used for examining the effects of repeated mild traumatic brain injury (r-mTBI) on synaptic plasticity in the hippocampus. The model replicates important features of r-mTBI in patients and is used in conjunction with in vitro electrophysiology.

Mild traumatic brain injuries (mTBIs) are a prevalent health issue in North America. There is increasing pressure to utilize ecologically valid models of ...