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Rui Jorge Nobre

CNC-UC - Center for Neuroscience and Cell Biology,
CIBB - Center for Innovative Biomedicine and Biotechnology,
IIIUC - Institute for Interdisciplinary Research,
ViraVector - Viral Vectors for Gene Transfer Core Facility

University of Coimbra

BIOGRAPHY

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PUBLICATIONS

Gene therapy for Parkinson's and Alzheimer's diseases: from the bench to clinical trials.

Current pharmaceutical design , 2011 | Pubmed ID: 21902665

Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease.

Human molecular genetics Sep, 2014 | Pubmed ID: 24817574

Gene therapy for the CNS using AAVs: The impact of systemic delivery by AAV9.

Journal of controlled release : official journal of the Controlled Release Society Nov, 2016 | Pubmed ID: 27637390

Hypoxia mimetic induces lipid accumulation through mitochondrial dysfunction and stimulates autophagy in murine preadipocyte cell line.

Biochimica et biophysica acta. General subjects Mar, 2017 | Pubmed ID: 27939617

Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases.

Journal of controlled release : official journal of the Controlled Release Society Sep, 2017 | Pubmed ID: 28687495

Gene Therapies for Polyglutamine Diseases.

Advances in experimental medicine and biology , 2018 | Pubmed ID: 29427115

Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease.

Molecular therapy : the journal of the American Society of Gene Therapy Sep, 2018 | Pubmed ID: 30087083

Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders.

Brain : a journal of neurology Feb, 2020 | Pubmed ID: 31738395

Protocol for the Characterization of the Cytosine-Adenine-Guanine Tract and Flanking Polymorphisms in Machado-Joseph Disease: Impact on Diagnosis and Development of Gene-Based Therapies.

The Journal of molecular diagnostics : JMD Jun, 2020 | Pubmed ID: 32205289

Trehalose alleviates the phenotype of Machado-Joseph disease mouse models.

Journal of translational medicine Apr, 2020 | Pubmed ID: 32272938

The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples.

Acta neuropathologica communications Aug, 2020 | Pubmed ID: 32867861

Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research.

Molecular therapy. Methods & clinical development Sep, 2020 | Pubmed ID: 32913880

Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening.

Pharmaceutics Oct, 2021 | Pubmed ID: 34683891

miRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3.

Nucleic acid therapeutics Jun, 2022 | Pubmed ID: 34878314

Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease.

Acta neuropathologica communications Mar, 2022 | Pubmed ID: 35305685

A new protocol for whole-brain biodistribution analysis of AAVs by tissue clearing, light-sheet microscopy and semi-automated spatial quantification.

Gene therapy Dec, 2022 | Pubmed ID: 36316447

Isolation of Extracellular Vesicles from Human Follicular Fluid: Size-Exclusion Chromatography versus Ultracentrifugation.

Biomolecules Feb, 2023 | Pubmed ID: 36830647

Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3.

Molecular therapy : the journal of the American Society of Gene Therapy May, 2023 | Pubmed ID: 37025062

RNA-based liposomes for oral cancer: From biophysical characterization to biological evaluation.

International journal of biological macromolecules Feb, 2024 | Pubmed ID: 38199539

Viral-based animal models in polyglutamine disorders.

Brain : a journal of neurology Apr, 2024 | Pubmed ID: 38284949

INSTITUTIONS

University of Coimbra

JOVE ARTICLES

Isolation of Adeno-Associated Viral Vectors Through a Single-Step and Semi-Automated Heparin Affinity Chromatography Protocol

Miguel M. Lopes^*,1,2,3,

Sara M. Lopes^*,1,2,3,

Rafael Baganha^1,2,4,

Carina Henriques^1,2,5,

Ana C. Silva^1,2,3,

Diana D. Lobo^1,2,3,

Luísa Cortes^1,2,3,6,

Luís Pereira de Almeida^*,1,2,4,5,

Rui Jorge Nobre^*,1,2,3,4

¹CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra,

²CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra,

³IIIUC - Institute for Interdisciplinary Research, University of Coimbra,

⁴ViraVector - Viral Vectors for Gene Transfer Core Facility, University of Coimbra,

⁵FFUC - Faculty of Pharmacy, University of Coimbra,

⁶MICC-CNC - Microscopy Imaging Center of Coimbra - CNC, University of Coimbra

Bioengineering

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Rui Jorge Nobre

CNC-UC - Center for Neuroscience and Cell Biology,CIBB - Center for Innovative Biomedicine and Biotechnology,IIIUC - Institute for Interdisciplinary Research,ViraVector - Viral Vectors for Gene Transfer Core Facility

University of Coimbra

Isolation of Adeno-Associated Viral Vectors Through a Single-Step and Semi-Automated Heparin Affinity Chromatography Protocol

CNC-UC - Center for Neuroscience and Cell Biology,
CIBB - Center for Innovative Biomedicine and Biotechnology,
IIIUC - Institute for Interdisciplinary Research,
ViraVector - Viral Vectors for Gene Transfer Core Facility