Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
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22:27 min
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May 6th, 2010
DOI :
May 6th, 2010
•Nynke L. van Berkum*1, Erez Lieberman-Aiden*2,3,4,5, Louise Williams*2, Maxim Imakaev6, Andreas Gnirke2, Leonid A. Mirny3,6, Job Dekker1, Eric S. Lander2,7,8
1Program in Gene Function and Expression, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 2Broad Institute of Harvard and Massachusetts Institute of Technology, 3Division of Health Sciences and Technology, Massachusetts Institute of Technology, 4Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Department of Mathematics, Harvard University , 5Department of Applied Mathematics, Harvard University , 6Department of Physics, Massachusetts Institute of Technology, 7Department of Systems Biology, Harvard Medical School, 8Department of Biology, Massachusetts Institute of Technology
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0:00
Title
1:03
Introduction
2:07
Crosslinking, Digestion, Marking of DNA Ends, and Blunt-End Ligation
9:46
Shearing and Size Selection
12:03
Biotin Pull-Down and Paired End Sequencing
16:38
Representative Hi-C Results
21:32
Conclusion
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