In vivo Near Infrared Fluorescence (NIRF) Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis

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17.9K Views

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09:43 min

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August 4th, 2011

DOI :

10.3791/2257-v

August 4th, 2011

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Marcella A. Calfon¹, Amir Rosenthal¹^,², Georgios Mallas¹^,³, Adam Mauskapf¹, R. Nika Nudelman², Vasilis Ntziachristos², Farouc A. Jaffer¹

¹Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, ²Institute for Biological and Medical Imaging, Helmholtz Zentrum München und Technische Universität München, ³Department of Electrical and Computer Engineering, Northeastern University

Резюме

We detail a new near-infrared fluorescence (NIRF) catheter for 2-dimensional intravascular molecular imaging of plaque biology in vivo. The NIRF catheter can visualize key biological processes such as inflammation by reporting on the presence of plaque-avid activatable and targeted NIR fluorochromes. The catheter utilizes clinical engineering and power requirements and is targeted for application in human coronary arteries. The following research study describes a multimodal imaging strategy that utilizes a n

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