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Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model

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20.3K Views

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11:49 min

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September 9th, 2011

DOI :

10.3791/3197-v

September 9th, 2011

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Alexandra E. Jantzen¹, Whitney O. Lane², Shawn M. Gage³, Justin M. Haseltine¹, Lauren J. Galinat¹, Ryan M. Jamiolkowski⁴, Fu-Hsiung Lin³, George A. Truskey¹, Hardean E. Achneck³

¹Department of Biomedical Engineering, Duke University , ²School of Medicine, Duke University , ³Department of Surgery, Duke University Medical Center, ⁴School of Medicine, University of Pennsylvania

Резюме

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Autologous Endothelial Progenitor Cell seeding Technology

Biocompatibility Testing

Cardiovascular Devices

Large Animal Model

Implantable Devices

Artificial Materials

Thromboemboli Formation

Ti Tubes

Blood derived Human Or Porcine Endothelial Progenitor Cells EPCs

Inferior Vena Cava IVC

Biocompatibility

Prothrombotic Environment

Bare Metal Surfaces

Endothelialize Devices

Antithrombotic Function

Peripheral Blood

Mononuclear Cell Fraction

Culture

Laparotomy

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0:05

Title

2:12

Preparing the EPCs for Seeding

4:01

Porcine Implantation Surgery: Part 1

6:16

Seeding the Implant

7:26

Porcine Implantation Surgery: Part 2

9:39

Representative Results

10:29

Conclusion

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