MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression

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08:26 min

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February 17th, 2012

DOI :

10.3791/3661-v

February 17th, 2012

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Mansoureh Sameni¹, Arulselvi Anbalagan¹, Mary B. Olive¹, Kamiar Moin¹^,², Raymond R. Mattingly¹^,², Bonnie F. Sloane¹^,²

¹Department of Pharmacology, Wayne State University , ²Barbara Ann Karmanos Cancer Institute, Wayne State University

Резюме

We have developed 3D coculture models for live-cell imaging in real-time of interactions among breast tumor cells and other cells in their microenvironment that impact progression to an invasive phenotype. These models can serve as preclinical screens for drugs to target paracrine-induced proteolytic, chemokine/cytokine and kinase pathways implicated in invasiveness.

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MAME Models

4D Live cell Imaging

Tumor Microenvironment Interactions

Malignant Progression

Coculture Models

Preinvasive Breast Lesions

Invasive Phenotype

Breast Epithelial Cells

Tumor Microenvironment

Myoepithelial Cells

Fibroblasts