The Use of Cystometry in Small Rodents: A Study of Bladder Chemosensation

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22.4K Views

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08:08 min

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August 21st, 2012

DOI :

10.3791/3869-v

August 21st, 2012

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Pieter Uvin¹^,²^,³, Wouter Everaerts¹^,²^,³, Silvia Pinto²^,³, Yeranddy A. Alpízar²^,³, Mathieu Boudes¹^,²^,³, Thomas Gevaert¹^,²^,³, Thomas Voets²^,³, Bernd Nilius²^,³, Karel Talavera²^,³, Dirk De Ridder¹^,³

¹Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven, Belgium, ²Laboratory for Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, Belgium, ³TRP Research Platform Leuven (TRPLe), KU Leuven, Belgium

Резюме

Cystometry is an efficient technique to measure bladder function of small animals in vivo. The bladder is continuously infused at rates controlled through an intravesical catheter, whereas the urethra is left free for micturition. This allows for repetitive filling and emptying of the bladder, while intravesical pressure and voided volume are recorded.

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