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JoVE Journal

Immunology and Infection

This content is Open Access.

A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting

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07:27 min

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May 16th, 2013

DOI :

10.3791/4316-v

May 16th, 2013

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Dumizulu L. Tembo¹, Jacqui Montgomery¹, Alister G. Craig², Samuel C. Wassmer³

¹Malawi-Liverpool-Wellcome Trust Clinical Research Programme, ²Liverpool School of Tropical Medicine, ³Department of Microbiology, Division of Medical Parasitology, New York University School of Medicine

Резюме

This method investigates the platelet-mediated clumping phenotype of Plasmodium falciparum-infected erythrocytes (pRBC) in clinical isolates. This is performed by isolating and co-incubating platelet-rich plasma and a suspension of pRBC.

Смотреть дополнительные видео

Platelet mediated Clumping

Plasmodium Falciparum infected Erythrocytes

Resource Poor Setting

Cerebral Malaria

Microvessels Obstruction

P Falciparum parasitized Red Blood Cells

Sequestration

Endothelial Cells

Post capillary Venules

Severe Pathological Outcomes

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