The scope of our research is to study metabolic disorder in relation to hypothalamic dysfunction. We're interested in studying the biochemical and cellular mechanism of targeted primary mammalian hypothalamic neuron, especially the one expressing leptin receptor. The hypothalamus is a complex brain region, involving the maintenance of feeding, sleeping, motivation, and metabolism.
And this imply a very diverse neural community. Only few of this population have been study thoroughly, and most of the other needs to further investigated and their cellular mechanism further explained. Hypothalamic neurons and their function and are investigated mainly with electrophysiology, chemogenetics, and optogenetics.
And these techniques are very informative in relation to understand animal behavior and brain circuitry. However, very little is known about the cellular and molecular mechanism that drive this behavior. And only by looking deeper at the cellular level, we can address this gaps.
