Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research

Our research focuses on understanding and ameliorating bone regeneration. Here we aim to extensively characterize tissue mineralization using various and complementary technical approaches to facilitate the early identification of promising candidates for bone regeneration therapies. To evaluate the quality and structure of newly mineralized tissue, we use complementary approaches, including high resolution 3D imaging with micro-CT associated with deep learning analysis.

Nano indentation, histological examinations, back scattering scanning electron microscope mapping, and Raman spectroscopy. Repair of bone defects is a major challenge in regenerative medicine. We developed explant models that facilitate the evaluation of bone regeneration, and the monitoring of mineralization over time.