JoVE Journal

Medicine

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Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice

A mouse model of human endoscopic skull base reconstruction has been developed that creates a semipermeable interface between the brain and nose using nasal mucosal grafts. This method allows researchers to study delivery to the central nervous system of high molecular weight therapeutics which are otherwise excluded by the blood-brain barrier when administered systemically.

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