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Bioengineering

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Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

9.0K Views

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07:47 min

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December 13th, 2015

DOI :

10.3791/53055-v

December 13th, 2015

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Yannan N. Dou¹, Robert A. Weersink²^,⁵, Warren D. Foltz⁵^,⁶, Jinzi Zheng⁵^,⁶, Naz Chaudary⁷, David A. Jaffray²^,³^,⁴^,⁵^,⁶, Christine Allen¹

¹Leslie Dan Faculty of Pharmacy, University of Toronto, ²Department of Radiation Oncology, University of Toronto, ³Medical Biophysics, University of Toronto, ⁴Institute of Biomaterials & Biomedical Engineering, University of Toronto, ⁵Techna Institute and Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, ⁶STTARR Innovation Center, University Health Network, ⁷Ontario Cancer Institute, University Health Network

Summary

AN MRI-compatible custom-designed laser-based heating apparatus has been developed to provide local heating of subcutaneous tumors in order to activate release of agents from thermosensitive liposomes specifically at the tumor region.

Explore More Videos

Thermosensitive Liposomes

Laser based Heating

Tumor Targeting

Triggered Drug Release

Chapters in this video

0:05

Title

2:00

Liposome Preparation

3:42

Subcutaneous Cervical Tumor Xenograft Implantation

5:08

Conformal Tumor Heating via Custom Laser Chamber

6:15

Results: Representative Tumor Laser Treatment Analyses

7:12

Conclusion

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