JoVE Journal

Neuroscience

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Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

1.1K Views

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10:28 min

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April 21st, 2023

DOI :

10.3791/64898-v

April 21st, 2023

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Aidan P. Nickerson¹^,², Graeme W. T. Newton¹, James H. O'Sullivan³, Manuel Martinez-Perez⁴, Anna C. Sales¹, Gethin Williams⁵, Anthony E. Pickering¹, James P. Dunham¹

¹Anaesthesia, Pain, and Critical Care Sciences, School of Physiology, Pharmacology, & Neuroscience, University of Bristol, ²Eli Lilly and Company, ³Department of Computer Science, University of Bristol, ⁴Department of Aerospace Engineering, University of Bristol, ⁵Research Computing, University of Bristol

Summary

APTrack is a software plugin developed for the Open Ephys platform that enables real-time data visualization and the closed-loop electrical threshold tracking of neuronal action potentials. We have successfully used this in microneurography for human C-fiber nociceptors and mouse C-fiber and Aδ-fiber nociceptors.

Chapters in this video

0:04

Introduction

1:29

Assembly of the Recording and Stimulating Apparatus

3:27

Software Setup and Identification and Phenotyping of Peripheral Neurons

5:43

Latency and Electrical Threshold Tracking

8:00

Results: Electrical Threshold Tracking of Single‐Neuron Action Potentials

9:43

Conclusion

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