Danwei Huangfu

Developmental Biology Program

Sloan Kettering Institute

BIOGRAPHY

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PUBLICATIONS

Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling.

Current biology : CB Sep, 2002 | Pubmed ID: 12372258

Hedgehog signalling in the mouse requires intraflagellar transport proteins.

Nature Nov, 2003 | Pubmed ID: 14603322

Analysis of mouse embryonic patterning and morphogenesis by forward genetics.

Proceedings of the National Academy of Sciences of the United States of America Apr, 2005 | Pubmed ID: 15755804

Cilia and Hedgehog responsiveness in the mouse.

Proceedings of the National Academy of Sciences of the United States of America Aug, 2005 | Pubmed ID: 16061793

Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates.

Development (Cambridge, England) Jan, 2006 | Pubmed ID: 16339192

All beta cells contribute equally to islet growth and maintenance.

PLoS biology Jul, 2007 | Pubmed ID: 17535113

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds.

Nature biotechnology Jul, 2008 | Pubmed ID: 18568017

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.

Nature biotechnology Nov, 2008 | Pubmed ID: 18849973

A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.

Cell stem cell Nov, 2009 | Pubmed ID: 19818703

Glucose and aging control the quiescence period that follows pancreatic beta cell replication.

Development (Cambridge, England) Oct, 2010 | Pubmed ID: 20823063

Human pluripotent stem cells: an emerging model in developmental biology.

Development (Cambridge, England) Feb, 2013 | Pubmed ID: 23362344

Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state.

Cell reports Mar, 2013 | Pubmed ID: 23478019

An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells.

Cell stem cell Aug, 2014 | Pubmed ID: 24931489

Stem cell epigenetics: looking forward.

Cell stem cell Jun, 2014 | Pubmed ID: 25032261

The iCRISPR platform for rapid genome editing in human pluripotent stem cells.

Methods in enzymology , 2014 | Pubmed ID: 25398343

Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells.

Nature biotechnology Jun, 2015 | Pubmed ID: 25798938

A CRISPR/Cas-Mediated Selection-free Knockin Strategy in Human Embryonic Stem Cells.

Stem cell reports Jun, 2015 | Pubmed ID: 26028531

Mechanisms underlying the formation of induced pluripotent stem cells.

Wiley interdisciplinary reviews. Developmental biology Jan-Feb, 2016 | Pubmed ID: 26383234

Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes.

Cell stem cell Jun, 2016 | Pubmed ID: 27133796

CRISPR/Cas9-Mediated Mutagenesis of Human Pluripotent Stem Cells in Defined Xeno-Free E8 Medium.

Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 27709569

CRISPR/Cas-Mediated Knockin in Human Pluripotent Stem Cells.

Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 27807834

The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells.

Cell stem cell Jan, 2017 | Pubmed ID: 27889317

Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development.

Cell stem cell Feb, 2017 | Pubmed ID: 28196600

INSTITUTIONS

Sloan Kettering Institute

JOVE ARTICLES

Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development

Zhong-Dong Shi^*,1,

Chew-Li Soh^*,1,

Zengrong Zhu^*,1,

Danwei Huangfu¹

¹Developmental Biology Program, Sloan Kettering Institute

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