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Medicine

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The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice

63.0K Views

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07:44 min

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August 18th, 2011

DOI :

August 18th, 2011

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Mette Richner¹, Ole J. Bjerrum², Anders Nykjaer¹, Christian B. Vaegter¹

¹The Lundbeck Foundation Research Center MIND, Department of Biomedicine, Aarhus University, ²Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen

Summary

The Spared Nerve Injury animal model is described here as a mouse model of peripheral neuropathic pain following partial denervation of the sciatic nerve by lesioning the tibial and common peroneal nerve branches, leaving the remaining sural nerve intact. Behavioral modification resulting from mechanical allodynia is quantified by von Frey filaments.

Chapters in this video

0:05

Title

1:56

Collecting Baseline von Frey Measurements Prior to Surgery

3:04

Anesthesia and Preparation for Surgery

4:14

Surgery

6:04

Post-surgical Care and von Frey Measurements

6:37

Results: von Frey Testing of 8-10 Week-old Mice Before and After Surgery

7:17

Conclusion

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